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KMID : 1134820160450030313
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 3 p.313 ~ p.320
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Attenuation Effects of Herbal Mixture Extract on Stress and Sleep Disturbance in Rats
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Jung An-Na
Lee Bo-Kyung
Lee Doo-Yi
Lee Ji-In
Jung Yi-Sook
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Abstract
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In the present study, we examined whether or not an herbal mixture extract (HME) has attenuation effects on immobilization stress and sleep disturbance in rats. Immobilization stress was induced by restricting movement using a constraint box for 2 h, and sleep disturbance was induced by exposure to 300 lx of constant light for 24 h and injection of caffeine (1 mg/kg, i.p.). Rats were orally treated with distilled water (vehicle) or HME for 3 weeks at different doses of 10, 30, and 100 mg/kg/d (HME Ⅰ, Ⅱ, and Ⅲ, respectively). In the immobilization model, HMEⅢ treatment significantly decreased adrenal gland weight, whereas HME Ⅱ and Ⅲ treatment reduced plasma levels of cortisol. HME Ⅱ and Ⅲ also reduced the level of IL-6. In the sleep disturbance model, HME Ⅱ and Ⅲ meaningfully reduced the plasma level of cortisol, and the increased plasma level of melatonin. HMEⅢ significantly increased body weight. HME reduced immobilization stress and ameliorated disturbance in rats. These findings suggest that HME may have beneficial potential for attenuation of sleep disturbance and stress.
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KEYWORD
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stress, sleep, herb, anti-stress, relaxation
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